miRTargetLink Human

=0){ mysqli_data_seek($res,$row); $resrow = (is_numeric($col)) ? mysqli_fetch_row($res) : mysqli_fetch_assoc($res); if (isset($resrow[$col])){ return $resrow[$col]; } } return false; } // making array of results $resultWeakArray = []; // while ($row = mysqli_fetch_assoc($resultWeak)) { // foreach($row as $field => $value) { // $resultWeakArray[] = $value; // } // } $mti =[]; $i = 0; $j = mysqli_num_rows($resultWeak); while($i < $j){ $result = mysqli_result($resultWeak, $i, $invType); $mti[$qval."##".$result] = mysqli_result($resultWeak, $i, "miRTarBase_ID"); array_push($resultWeakArray, $result); $i++; } $resultStrongArray = []; // while ($row = mysqli_fetch_assoc($resultStrong)) { // foreach($row as $field => $value) { // $resultStrongArray[] = $value; // } // } $i = 0; $j = mysqli_num_rows($resultStrong); while($i < $j){ $result = mysqli_result($resultStrong, $i, $invType); $mti[$qval."##".$result] = mysqli_result($resultStrong, $i, "miRTarBase_ID"); array_push($resultStrongArray, $result); $i++; } $resultMirandaArray = []; // while ($row = mysqli_fetch_assoc($resultMiranda)) { // foreach($row as $field => $value) { // $resultMirandaArray[] = $value; // } // } $i = 0; $j = mysqli_num_rows($resultMiranda); while($i < $j){ $result = mysqli_result($resultMiranda, $i, $invType); array_push($resultMirandaArray, $result); $i++; } function getConsensus($x, $y){ $z = []; foreach($x as $a){ if(in_array($a, $y)){ array_push($z, $a); } } return $z; } function getDistinct($x, $y){ $z = []; foreach($x as $a){ if(!in_array($a, $y)){ array_push($z, $a); } } return $z; } $weakDistinct = getDistinct($resultWeakArray, $resultStrongArray); $miRandaDistinct = getDistinct($resultMirandaArray, $resultStrongArray); $miRandaDistinct = getDistinct($resultMirandaArray, $resultWeakArray); $resultSize = sizeOf($weakDistinct)+sizeOf($resultStrongArray)+sizeOf($miRandaDistinct); if(sizeOf($resultStrongArray)+sizeOf($weakDistinct)+sizeOf($miRandaDistinct) > 0){ ?>

miRTargetLink found

  • interactions with strong support

  • interactions with weak support

  • predicted interactions

Double click to generate interaction landscape
(opens in new tab)"; $strong = "strong experimental evidence"; $weak = "weaker experimental evidence"; $miranda = "prediction data"; $qNode = ["id" => $motherId, "label" => $qval, "color" => "#6E3E0B", "font" => "16px arial white", "shape" => "box", "title" => "".$qval."
    ".$clickInfo."
", "fixed" => true]; $rNodes = [$qNode]; $rEdges = []; for ($i = 0; $i < sizeOf($weakDistinct); $i++) { $n++; array_push($idsWeak, $n); array_push($rNodes, ["id" => $n, "label" => $weakDistinct[$i], "color" => "#346980", "font" => "16px arial white", "shape" => "box", "title" => "".$weakDistinct[$i]."
  • Interaction is backed up by ".$weak."
    • ".$clickInfo."
"]); } for ($i = 0; $i < sizeOf($resultStrongArray); $i++) { $n++; array_push($idsStrong, $n); array_push($rNodes, ["id" => $n, "label" => $resultStrongArray[$i], "color" => "#246327", "font" => "16px arial white", "shape" => "box", "title" => "".$resultStrongArray[$i]."
  • Interaction is backed up by ".$strong."
    • ".$clickInfo."
"]); } // print_r($rNodes); for ($i = 0; $i < sizeOf($miRandaDistinct); $i++) { $n++; array_push($idsMiranda, $n); array_push($rNodes, ["id" => $n, "label" => $miRandaDistinct[$i], "color" => "#FFDA00", "font" => "16px arial black", "shape" => "box", "title" => "".$miRandaDistinct[$i]."
  • Interaction is backed up by ".$miranda."
    • ".$clickInfo."
"]); } $fac = 0; if($resultSize > 500){$fac = 400;} if($resultSize > 1000){$fac = 800;} if($resultSize > 1300){$fac = 1100;} if($resultSize < 300){$fac = -150;} for ($i = 0; $i < sizeOf($idsStrong); $i++) { $l = 300+$fac; array_push($rEdges, ["from" => $motherId, "to" => $idsStrong[$i], "color" => "#246327", "length" => $l]); } for ($i = 0; $i < sizeOf($idsWeak); $i++) { $l = 600+$fac; array_push($rEdges, ["from" => $motherId, "to" => $idsWeak[$i], "color" => "#346980", "length" => $l]); } for ($i = 0; $i < sizeOf($idsMiranda); $i++) { $l = 1000+$fac; array_push($rEdges, ["from" => $motherId, "to" => $idsMiranda[$i], "color" => "#FF5E00", "length" => $l]); } ?>

Network tips

  • Hover over any node or edge to see more info about the interaction.
  • Double click on a gene or microRNA to open its interaction landscape in a new tab.
  • Right click -> 'save image as...' to download network as png image.
  • Click on microRNAs or genes in the table below to open a genecards or miRBase link in a new tab.
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Edit network:

Generate subnetwork for selection:

Download interaction data

> 0){ foreach($resultStrongArray as $s){ ?> 0){ foreach($weakDistinct as $w){ ?> 0){ foreach($miRandaDistinct as $p){ ?>
Evidence category miRTarBase ID
title= target="_blank"> title= target="_blank"> Strong " target="_blank" title="open miRTarBase page for []">
title= target="_blank"> title= target="_blank"> Weak " target="_blank" title="open miRTarBase page for []">
title= target="_blank"> title= target="_blank"> Prediction N/A

Table filter:

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Search by microRNA

Interaction landscape for a single microRNA:


Target-gene overlap between multiple microRNAs:

To view an example, leave fields empty and click search

Search by gene symbol

Interaction landscape for a single gene symbol:


MicroRNA interaction overlap between multiple genes:

To view an example, leave fields empty and click search

Over-representation analysis

Perform Over-representation analysis with GeneTrail2, a tool for statistical analysis of molecular signatures that was developed in the Chair for Bioinformatics at the University of Saarland.

Perform Over-representation analysis for:

0){ $_SESSION['strong'.$sessionkey] = $resultStrongArray; $button2 = "Strong- and weaker support"; $title2 = "Interactions with strong and/or weaker experimental support"; $_SESSION['SWbool'.$sessionkey] = True; $_SESSION['SWval'.$sessionkey] = array_merge($resultStrongArray, $weakDistinct); ?>

Network information

The length of the edges is an extra indicator for the type of evidence that supports the interaction. The center node (brown) depicts the query microRNA or gene, the nodes closest to the query node (green) depict interactions that are backed up by strong experimental evidence such as Reporter Gene Assay. Second (blue) are the intereactions that are backed up by weaker experimental evidence such as Microarray. The outer most nodes (yellow) depict intereactions are backed up only by prediction algorithms.

View the manual (opens in a new tab)