LOCUS       KV809384.1             13671 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  KV809384.1 Staphylococcus sp. HMSC065C09 genomic scaffold
            Scaffold66, whole genome shotgun sequence.
ACCESSION   KV809384
VERSION     KV809384.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.0.0
            Run date     :: 2023-10-04 10:42:37
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 4895
            Orig. end    :: 18566
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13671
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10710]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10710
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..13671
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13671
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     gene            697..1335
                     /ID="gene-HMPREF2862_05100"
                     /Name="HMPREF2862_05100"
                     /gbkey="Gene"
                     /gene_biotype="protein_coding"
                     /locus_tag="HMPREF2862_05100"
                     /source="Genbank"
     CDS             697..1335
                     /Dbxref="NCBI_GP:OFS52001.1"
                     /ID="cds-OFS52001.1"
                     /Name="OFS52001.1"
                     /gbkey="CDS"
                     /gene="HMPREF2862_05100"
                     /inference="EXISTENCE: similar to AA
                     sequence:SwissProt:Q4L7T0.1"
                     /locus_tag="HMPREF2862_05100"
                     /phase="0"
                     /product="redox-sensing transcriptional repressor Rex"
                     /protein_id="OFS52001.1"
                     /source="Protein Homology"
                     /transl_table=11
                     /translation="MAHNKSKIPRATLKRLPLYYRFVNTLKSKGIDRVNSKAISEALNI
                     ESATIRRDFSYFGELGKKGYGYNIDSLLEFFKTALSDSDNIYIALVGVGNLGRALLTYN
                     FSIHDEMTITEAFDIDEQIVGTEIGDVSVHHMNDLKKVLNAQKINVVILTTPEEAAQQV
                     ANQLVEANIQGILNFTPARIEVPNTVQVHHIDLGIELQSLLFFMKNYSN"
     gene            1534..2631
                     /ID="gene-HMPREF2862_05105"
                     /Name="HMPREF2862_05105"
                     /gbkey="Gene"
                     /gene_biotype="protein_coding"
                     /locus_tag="HMPREF2862_05105"
                     /source="Genbank"
     CDS             1534..2631
                     /Dbxref="NCBI_GP:OFS52002.1"
                     /ID="cds-OFS52002.1"
                     /Name="OFS52002.1"
                     /gbkey="CDS"
                     /gene="HMPREF2862_05105"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_016931063.1"
                     /locus_tag="HMPREF2862_05105"
                     /phase="0"
                     /product="hypothetical protein"
                     /protein_id="OFS52002.1"
                     /source="Protein Homology"
                     /transl_table=11
                     /translation="VIWMIISGLIVGILLGFVMQRTRFCLAGGFRDMYVQKNNKMFYAL
                     LVAITVQSIGLLILTGLNVISIPDSTFPIIGTIIGGFIFGIGIVLAGGCATGTWYRAGE
                     GLIGSWIALVLYAVTAAITKTGILLPVMTWINKPTNINANMSQTTGIPMWVFTLVLTII
                     TIIFVTKTLRKPKPKFAVPKLKQKYSGLRHYLFEKRYHPFVAGIAVGLIALIAWPMSIS
                     TGRDYGLGITTPSANLITFLITGDTKLIDWGVLLILGIFLGSYIAAKGSREFKWRLPDK
                     KTIRNSAIGGICMGFGASVAGGCSIGNGLVETAIMSWKGWIALGSMILGVWFMSYFIFI
                     RPMKKLEKQTSKSQATTATKQVQTT"
     gene            2651..2875
                     /ID="gene-HMPREF2862_05110"
                     /Name="HMPREF2862_05110"
                     /gbkey="Gene"
                     /gene_biotype="protein_coding"
                     /locus_tag="HMPREF2862_05110"
                     /source="Genbank"
     CDS             2651..2875
                     /Dbxref="NCBI_GP:OFS52003.1"
                     /ID="cds-OFS52003.1"
                     /Name="OFS52003.1"
                     /gbkey="CDS"
                     /gene="HMPREF2862_05110"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_019469551.1"
                     /locus_tag="HMPREF2862_05110"
                     /phase="0"
                     /product="oxidoreductase"
                     /protein_id="OFS52003.1"
                     /source="Protein Homology"
                     /transl_table=11
                     /translation="MLYELGTVGMVCPFPLIEAQKKMQTLDSGDELKIDFDCTQATEAI
                     PNWAAEQGYPVTNYEQLDDASWTITIQKA"
     gene            2996..4240
                     /ID="gene-HMPREF2862_05115"
                     /Name="HMPREF2862_05115"
                     /gbkey="Gene"
                     /gene_biotype="protein_coding"
                     /locus_tag="HMPREF2862_05115"
                     /source="Genbank"
     CDS             2996..4240
                     /Dbxref="NCBI_GP:OFS52004.1"
                     /ID="cds-OFS52004.1"
                     /Name="OFS52004.1"
                     /gbkey="CDS"
                     /gene="HMPREF2862_05115"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_016931062.1"
                     /locus_tag="HMPREF2862_05115"
                     /phase="0"
                     /product="ammonia permease"
                     /protein_id="OFS52004.1"
                     /source="Protein Homology"
                     /transl_table=11
                     /translation="MKMDDTIFLFLCTLLVWIMTPGLSLFYGGLVQSKNVLNTVMQSMA
                     AMIIVTFTWVALGFSLSFGTGNALIGNFDLIGLQHVGFAVNDQLSPHIPFALFMLFQMM
                     FCTIAVSILSGSIAERMKFFPFIIFIFLWVILIYSPVAHWVWGRGWIQQLGALDYAGGT
                     VVHITSGLSGLILAIMIGNGKKIEKIQPHNLLITLIGGILVWVGWYGFNTGSAYTLNDV
                     ALTSFVNTIIAASGGALSWLVVGYCITKKLSLLGLLSGVLAGLVAITPAAGYVSYFSAY
                     IISITGGIVCYLVINVIKVKYKYNDTLDAFGIHGAGGIVGAILTGVFQSHYVNNDVSNG
                     LIYTGDVHSILIQILAVVVVLCYTIVLTWIIGKILQKIMPIATTEEEDKAGLDQLVHGE
                     KAYFYGELNKLNKRY"
     gene            4341..5300
                     /ID="gene-HMPREF2862_05120"
                     /Name="HMPREF2862_05120"
                     /gbkey="Gene"
                     /gene_biotype="protein_coding"
                     /locus_tag="HMPREF2862_05120"
                     /source="Genbank"
     CDS             4341..5300
                     /Dbxref="NCBI_GP:OFS52005.1"
                     /ID="cds-OFS52005.1"
                     /Name="OFS52005.1"
                     /gbkey="CDS"
                     /gene="HMPREF2862_05120"
                     /gene_functions="regulatory (smcogs) SMCOG1078:LacI family
                     transcription regulator (Score: 194.9; E-value: 3.5e-59)"
                     /gene_kind="regulatory"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_011275298.1"
                     /locus_tag="HMPREF2862_05120"
                     /phase="0"
                     /product="LacI family transcriptional regulator"
                     /protein_id="OFS52005.1"
                     /source="Protein Homology"
                     /transl_table=11
                     /translation="MKNISDIAKLAGVSKSTVSRFLNGGSVSHQTKEKLSRIIEEHDYQ
                     PNQFAQSLRAKHTNLIGAIIPRMNSHAVDETVKGIVSVCHQHQYQLLLNYTGLDIRAEI
                     GALDTFSRSKVDGIILMATTLTDEHLEVIEKLNVPVILVGQSYPNLHSIIHDDYQAGFI
                     VGEQIGRKKHKNVVFFGVSEEDVAVGIKRKQGIIDGLKKYDVYPEIYLTSFRYEEAKND
                     VSKKLKNARGIDALIGATDPIALAIHKFYSQQNNATGNYHIFGFGGDPMTQLVTPAITT
                     VKFNYFKAGTYAMNQLNELIFSKNAVSKTVIPVEIEDF"
     gene            5385..6869
                     /ID="gene-HMPREF2862_05125"
                     /Name="HMPREF2862_05125"
                     /gbkey="Gene"
                     /gene_biotype="protein_coding"
                     /locus_tag="HMPREF2862_05125"
                     /source="Genbank"
     CDS             5385..6869
                     /Dbxref="NCBI_GP:OFS52006.1"
                     /ID="cds-OFS52006.1"
                     /Name="OFS52006.1"
                     /gbkey="CDS"
                     /gene="HMPREF2862_05125"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_016931060.1"
                     /locus_tag="HMPREF2862_05125"
                     /phase="0"
                     /product="sucrose-6-phosphate hydrolase"
                     /protein_id="OFS52006.1"
                     /source="Protein Homology"
                     /transl_table=11
                     /translation="MAEWSREERYRRIEDVDKKYLENLKQQVKASRFRQIFHIQPETGL
                     LNDPNGLIYHNGKYYVSHQWFPLGAVHGLKYWFNYTSDDLVAFEPQDTLIKPDTYYDSH
                     GVYSGSAFDHNGDLYYMYTGNHRDEQWNRYASQMIAKVQSNGEITKFDEPVIPSQPEGY
                     TSHFRDPKVFELNNEYYAIIGAQTNEELGCCLIYKTNDKQLNQWSYCGEIDTKLKNFGY
                     MWECPDYFKLDSKDILLFSPQGIEPQGDQFRNIYQSGYLIGDLNFDSLSFDHSEFVELD
                     NGFDFYAPQTFLDENGNRVLIGWMGLPEINYPTDEEGWAHCLTIPRVLTIENNQLRQRP
                     FKGLERLRKNKETALGYANKFNRKLHPYEGKQYELIIDIIENDASKIYFELRTSKQNNT
                     KIIYNTREQKITLDRSESGLLPENVQDLTRSTILDSPLTRLQIFVDTSSIEIFCNDGER
                     VLTSRIFPDENATGIETSTETGQVYLKFTKYELKDE"
     gene            6873..7838
                     /ID="gene-HMPREF2862_05130"
                     /Name="HMPREF2862_05130"
                     /gbkey="Gene"
                     /gene_biotype="protein_coding"
                     /locus_tag="HMPREF2862_05130"
                     /source="Genbank"
     CDS             6873..7838
                     /Dbxref="NCBI_GP:OFS52007.1"
                     /ID="cds-OFS52007.1"
                     /Name="OFS52007.1"
                     /gbkey="CDS"
                     /gene="HMPREF2862_05130"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276:PfkB domain protein (Score: 217.7; E-value:
                     3.6e-66)"
                     /gene_kind="biosynthetic-additional"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_016931059.1"
                     /locus_tag="HMPREF2862_05130"
                     /phase="0"
                     /product="fructokinase"
                     /protein_id="OFS52007.1"
                     /source="Protein Homology"
                     /transl_table=11
                     /translation="MRKLYGIGEALIDFIPNVKNSELKDVEQFSRQVGGAPANVVSVAR
                     KMGASTEMVTQLGNDAFGDIIVETLKDIGVGTQFIKRTDQANTALAFVSLKEDGQRDFS
                     FYRKPSADMLYKAEYLNEITIKPNDVLHFCSVDLVESNMKEAHKSMVNKFKSANATIVF
                     DPNVRLPLWQNAEACKEAIHEFLPKANVIKISDEELEFITGEADEDKAIQSLFEGSVEA
                     VIYTQGAAGASIILKDGTKIHHGGFKVKAIDTTGAGDAFIGAAISRMLLSDELNITKLL
                     KEEGQDILRFSNMVAAKVTTKYGAIESIPTIEDVTTELNK"
     gene            complement(7956..8672)
                     /ID="gene-HMPREF2862_05135"
                     /Name="HMPREF2862_05135"
                     /gbkey="Gene"
                     /gene_biotype="protein_coding"
                     /locus_tag="HMPREF2862_05135"
                     /source="Genbank"
     CDS             complement(7956..8672)
                     /Dbxref="NCBI_GP:OFS52008.1"
                     /ID="cds-OFS52008.1"
                     /Name="OFS52008.1"
                     /gbkey="CDS"
                     /gene="HMPREF2862_05135"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_000688500.1"
                     /locus_tag="HMPREF2862_05135"
                     /phase="0"
                     /product="DNA-binding response regulator"
                     /protein_id="OFS52008.1"
                     /source="Protein Homology"
                     /transl_table=11
                     /translation="MKIFICEDDVKQRENMVSIINNYIMIEEKPMEIALATDDPYEVIE
                     KSKEMNDVGCYFLDIQLEADINGIKLGSEIRKYDPIGNIIFVTSHSELTYLTFVYKVSA
                     MDFIFKDDPSQLQSRIIDCLETAHTRLKLLSKESTVETIELKRGSNSIYVQYDDVMFFE
                     SSTKSHRLIAHLDNRQIEFYGNLKELAQLDERFFRCHNSFVVNRHNIESIDSKERIVNF
                     KNGEHCFASVRNVKKI"
     gene            complement(8691..9974)
                     /ID="gene-HMPREF2862_05140"
                     /Name="HMPREF2862_05140"
                     /gbkey="Gene"
                     /gene_biotype="protein_coding"
                     /locus_tag="HMPREF2862_05140"
                     /source="Genbank"
     CDS             complement(8691..9974)
                     /Dbxref="NCBI_GP:OFS52009.1"
                     /ID="cds-OFS52009.1"
                     /Name="OFS52009.1"
                     /gbkey="CDS"
                     /gene="HMPREF2862_05140"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_002455089.1"
                     /locus_tag="HMPREF2862_05140"
                     /phase="0"
                     /product="histidine kinase"
                     /protein_id="OFS52009.1"
                     /source="Protein Homology"
                     /transl_table=11
                     /translation="MDVLSNVPLAFFQGFLLFLIAKIILDISYTKRDYLAILVVIIPSA
                     FLFIYLGSISILYLLIGCGLILYTKVKLYSLIAVLSSAILMFFSNFLGFLFVVLVEKHT
                     QNYVIISFSYIVIFFAISLVLAFSVQILLKKLMQSYLSINKTYLTIISLVLVLSFIILY
                     VYSQIPNINNSSLKMYGLIFIGIILFFTVLIIFISNYMIKELRYKRNMEEIETYYEYTL
                     QIESINNEMRKFRHDYVNILTTMSEYIREDDMPGLRQYFNENIVPMKDNLQMKSIKING
                     TENLKVRAIKGLVTTKILQAQEKNIPISIEVPELVEHIEMNTIDLSRIIGIITDNAIEA
                     SETLEDALIRIAFINTDSSVMFIVMNKCKEDMPRIHELFQERFSTKGENRGLGLSTLKE
                     ITDSTENVLLDTTIENGYFIQKVEIINN"
     gene            complement(10001..10141)
                     /ID="gene-HMPREF2862_05145"
                     /Name="HMPREF2862_05145"
                     /gbkey="Gene"
                     /gene_biotype="protein_coding"
                     /locus_tag="HMPREF2862_05145"
                     /source="Genbank"
     CDS             complement(10001..10141)
                     /Dbxref="NCBI_GP:OFS52010.1"
                     /ID="cds-OFS52010.1"
                     /Name="OFS52010.1"
                     /gbkey="CDS"
                     /gene="HMPREF2862_05145"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_019835517.1"
                     /locus_tag="HMPREF2862_05145"
                     /phase="0"
                     /product="accessory regulator AgrD"
                     /protein_id="OFS52010.1"
                     /sec_met_domain="TIGR04223 (E-value: 1e-13, bitscore: 41.5,
                     seeds: 127, tool: rule-based-clusters)"
                     /source="Protein Homology"
                     /transl_table=11
                     /translation="MTVLFDLFIKFFSFLLESVGTLASYTPCATYFDEPEVPEELTNLN
                     R"
     gene            complement(10144..10710)
                     /ID="gene-HMPREF2862_05150"
                     /Name="HMPREF2862_05150"
                     /gbkey="Gene"
                     /gene_biotype="protein_coding"
                     /locus_tag="HMPREF2862_05150"
                     /source="Genbank"
     CDS             complement(10144..10710)
                     /Dbxref="NCBI_GP:OFS52011.1"
                     /ID="cds-OFS52011.1"
                     /Name="OFS52011.1"
                     /gbkey="CDS"
                     /gene="HMPREF2862_05150"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_002488058.1"
                     /locus_tag="HMPREF2862_05150"
                     /phase="0"
                     /product="histidine kinase"
                     /protein_id="OFS52011.1"
                     /sec_met_domain="AgrB (E-value: 7e-34, bitscore: 107.1,
                     seeds: 181, tool: rule-based-clusters)"
                     /source="Protein Homology"
                     /transl_table=11
                     /translation="LKAIDNKIEQFALYLQRKNNLDHIQFLKVRLGLQVVVSNLSKTIV
                     TYGVALIFHTFLYTLFTHVSYFLVRRYAHGAHAKSPLLCHVQNLALFVGLPWLLVYFQV
                     NLGIMYSVVAIGTVLIIYYAPSATKKQPIPSHLKMKKKLLSVIITMVLLIISFLAPEPF
                     KQLILLGITLESITLLPIFFPREDY"
     gene            complement(11440..12225)
                     /ID="gene-HMPREF2862_05155"
                     /Name="HMPREF2862_05155"
                     /gbkey="Gene"
                     /gene_biotype="protein_coding"
                     /locus_tag="HMPREF2862_05155"
                     /source="Genbank"
     CDS             complement(11440..12225)
                     /Dbxref="NCBI_GP:OFS52012.1"
                     /ID="cds-OFS52012.1"
                     /Name="OFS52012.1"
                     /gbkey="CDS"
                     /gene="HMPREF2862_05155"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294:Nitrilase/cyanide hydratase and apolipoprotein
                     (Score: 188.6; E-value: 2.3e-57)"
                     /gene_kind="biosynthetic-additional"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_016931057.1"
                     /locus_tag="HMPREF2862_05155"
                     /phase="0"
                     /product="hydrolase"
                     /protein_id="OFS52012.1"
                     /source="Protein Homology"
                     /transl_table=11
                     /translation="MKIQLFQFYVSYGNVEKNENKIINWFENKLEEDTEVVVLPEMWNN
                     GYALDELNEKADRELSRSFPFIQSLAKQYNVDIVAGSVSNIRNGKVYNTAFTVSKNGHR
                     INKYDKVHLVPMLDEPTYLEDGKTVPEPFPLSSGTQATQIICYDLRFPELLRYPARNGA
                     QIAFFVAQWPTPRLNHWRVLLQARAIENDMFVVACNGTGNDSNTDYAGHSMIINPNGDI
                     LAELGQDEDTIAFNIDLNEVDVQRENIPVFKNLKPNLYK"
     gene            complement(12418..13041)
                     /ID="gene-HMPREF2862_05160"
                     /Name="HMPREF2862_05160"
                     /gbkey="Gene"
                     /gene_biotype="protein_coding"
                     /locus_tag="HMPREF2862_05160"
                     /source="Genbank"
     CDS             complement(12418..13041)
                     /Dbxref="NCBI_GP:OFS52013.1"
                     /ID="cds-OFS52013.1"
                     /Name="OFS52013.1"
                     /gbkey="CDS"
                     /gene="HMPREF2862_05160"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /inference="EXISTENCE: similar to AA
                     sequence:RefSeq:WP_016931056.1"
                     /locus_tag="HMPREF2862_05160"
                     /phase="0"
                     /product="nitroreductase"
                     /protein_id="OFS52013.1"
                     /sec_met_domain="PF00881 (E-value: 1.2e-13, bitscore: 41.8,
                     seeds: 78, tool: rule-based-clusters)"
                     /source="Protein Homology"
                     /transl_table=11
                     /translation="MGLFSKSKTKPFLQEIEDRRTIYSTETTISISDKELEDMIEHIIK
                     YTPSAFNSQSTRIVLLLNDQHHKFWDNTKIVLKDVMGPDRDFTPTEQRIDGFKHAYGTI
                     LYFEDEDVIKGLQEQMPNYADNFANWSVQTNAMHQFAIWTALSSKGIGASLQHYNPLVD
                     QITTQEFDIPASWKLVAQMPFGDIREKAGEKEIQPTNNRLIIKK"
     CDS             13226..13671
                     /ID="cds-HMPREF2862_05165"
                     /Note="incomplete; too short partial abutting assembly gap;
                     missing stop"
                     /gbkey="CDS"
                     /gene="HMPREF2862_05165"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS+"
                     /locus_tag="HMPREF2862_05165"
                     /phase="0"
                     /product="hypothetical protein"
                     /pseudo="true"
                     /source="GeneMarkS+"
                     /transl_table=11
                     /translation="MKKKIAHTGLILALGTSMLGNENVVKAVENNQQATNEVNSSKVSS
                     DTDTQERQNSSNNINENHQSDTQDSTQLEKNNNNQNSGESDTSSNNENDANQNSDNTVD
                     QSNASDNSNSGSNTDLNNGDDTNNSGDNDTINPNDGEQPGDNDS"
ORIGIN
        1 ccatgtagaa cagttttgat tttactctca tactgataac catcaagttg ttcgaattga
       61 ttagttaaag attcatagcg ttccatatgt tgttgatatt cttcggaatc atagttagat
      121 gcttgatcag ctagccagtt cgtttcttct ttaattagaa gttccatttt ttttaaatgt
      181 tcaaacggtt ttgacatttc ttcgaagact gaagcggatg aattaagtgt catttgctgt
      241 gttaaataac ccatacgtaa atttttgatt tttgatatat gaccgctatc atagtcttca
      301 acaccggcaa tgattttcat taaagtcgat ttaccggcac cgtttctgcc tacgacacca
      361 attcgttcgc ctgtttttac ttcgaaattc acacgcgtaa aaatatcttc gccatcaaat
      421 gatttcgaaa tatcgtttaa ttgcaagagt atcattcagg tttcaccttt ctatttataa
      481 gtttattact cgaaattaga ttgtatatta ctctatattt taccgtataa cttagtttct
      541 tgaaactaag ttatttattt ttaaaatatg ttaaggtata atattccagt attcataata
      601 ggacataatg acatttttaa atttaaaacg tatagcactc aaaatagttt ggatacatag
      661 attataaaat tcaaacataa aggagggata ttttaaatgg ctcataataa atctaaaatt
      721 ccacgggcaa ctttgaagcg attaccttta tattacagat tcgttaacac actcaagtct
      781 aaaggcattg atagggttaa ttctaaggct attagtgagg cacttaatat cgaatcagca
      841 accatccgaa gagatttctc ttactttgga gaattaggca aaaaaggtta cggttacaat
      901 atagatagtc tattagaatt ctttaaaaca gcactaagtg atagtgataa tatatacata
      961 gctttagtag gtgttggtaa tttaggtcga gcacttttga catataactt ttcaattcat
     1021 gatgaaatga caataactga ggcttttgat atagatgaac agattgtcgg aacagagatt
     1081 ggtgatgtat ctgtgcatca tatgaacgat ttaaaaaaag tactcaatgc tcaaaaaata
     1141 aatgttgtaa tattaactac accagaagaa gcggcacaac aggttgcaaa tcaattagtt
     1201 gaagctaata ttcaaggtat actaaatttc acaccagcta gaatagaagt acctaatacc
     1261 gtacaagtgc atcatattga cttgggcata gaattgcaat cattgctatt ctttatgaaa
     1321 aactattcta attaaatttt tatatttata ttcttacatc cttctttata agagggatgt
     1381 tttttaattt acgtttaaaa ttcattaatt tcatttagta ttgaaaacat catattatta
     1441 aaaatcaaaa gcgtttaatt ttaagatgtt gccaaattta gtacaattga ttataatacc
     1501 ttagtaaaat aatcgggaaa ggatgaaatg atagtgatat ggatgattat tagtggtctt
     1561 atagtaggta tattattagg gtttgtgatg caacgtacac gcttctgttt agctggtggc
     1621 ttcagagata tgtacgttca aaaaaataat aaaatgtttt atgccttatt agttgctatt
     1681 acagtccaaa gtattggact acttatttta accggattaa atgttatatc tatcccagat
     1741 agtacatttc caattatagg tacaattatt ggtggtttta tatttggaat cggtattgta
     1801 ttagcaggag gatgtgctac aggtacatgg tatcgagctg gtgaaggttt gattggcagt
     1861 tggatagcgc tcgtactata tgctgtaact gccgctatta ctaaaactgg tattttactt
     1921 ccagtaatga catggattaa taaacctaca aacattaatg caaatatgtc tcagactacc
     1981 ggtattccta tgtgggtgtt tacgttagta ttaacaatta taactatcat ttttgtaact
     2041 aaaacattac gtaaaccaaa acccaaattt gcagttccaa agcttaaaca aaagtatagt
     2101 ggcttgagac actatttatt tgaaaaacga taccatccat ttgtggctgg tattgcagta
     2161 gggttaattg ctttgatagc ttggccaatg agtatttcta ctggaagaga ttacggctta
     2221 ggcattacta caccttcagc aaacttaatt acctttttaa ttacaggtga tactaagcta
     2281 attgattggg gagtattatt gattttaggt atattcttag gttcttatat tgctgctaaa
     2341 ggatcacgtg aatttaaatg gcgattacct gataagaaga ccattcgcaa tagtgctatt
     2401 ggtggtattt gtatgggatt tggtgcttca gtagctggag gatgttcaat tggaaatggt
     2461 ttagtagaaa ctgctatcat gtcttggaaa ggatggatag cacttggttc tatgatttta
     2521 ggtgtatggt ttatgagtta ctttatattt attagaccaa tgaaaaaatt agaaaaacaa
     2581 acatctaagt ctcaagcaac aacagcgaca aaacaagtac aaacgactta attaatttgg
     2641 aggtaataca atgttatatg aattaggtac tgtaggtatg gtttgtccat tcccattaat
     2701 agaagcgcaa aagaaaatgc aaacactaga tagtggtgat gaacttaaaa ttgattttga
     2761 ttgtacacaa gcaacagaag ctattcctaa ttgggcagcc gagcaaggtt atccagttac
     2821 gaattatgaa caattagacg atgcttcatg gacaattaca attcagaaag cttaaaacaa
     2881 aataagcatg taaagcgtct gtgttatatt atgtaacata ttgtgtcatt ttatcttacg
     2941 tatttttgct attcaattta gtatcattat gatattttta aaggaagtgg taattatgaa
     3001 gatggatgac acaatttttt tatttctttg cactttactt gtatggatta tgacaccagg
     3061 tcttagctta ttttacggtg gtctagttca atcaaagaat gttttgaata cagtaatgca
     3121 aagtatggca gcaatgatta tcgtgacttt cacatgggtt gcattaggat tttcattaag
     3181 ctttggaact ggaaatgctt tgatagggaa ttttgattta attgggttac agcatgttgg
     3241 ctttgcagtt aatgatcaat taagtccgca tattccattt gcattattta tgctattcca
     3301 aatgatgttt tgtacaattg cagtttcaat cctttcaggt tcaatcgctg aacgtatgaa
     3361 attctttcca tttattatct ttatcttttt atgggtgatt ttaatatata gtccagttgc
     3421 gcattgggtg tggggccgag gttggattca acaacttggt gctcttgatt atgcaggtgg
     3481 tacagttgta catatcacat ctggactctc aggactaatt ttggctatta tgataggtaa
     3541 tggtaaaaaa attgaaaaaa tacagccaca taatctttta atcactttaa ttggcggtat
     3601 tttagtatgg gtaggttggt atggctttaa cacaggtagt gcatatactt taaatgatgt
     3661 cgcattaaca tcatttgtaa atacgattat tgctgcaagt ggtggcgctc ttagctggtt
     3721 agtagttggg tactgtatta ctaagaaatt aagtttactt gggttgttat caggcgtgtt
     3781 ggcagggtta gtcgctatta caccggcagc aggctatgtt agttatttca gtgcttatat
     3841 tatttcaatt acaggtggaa tcgtttgtta ccttgttatt aatgtaatta aagtgaaata
     3901 taaatataat gatacacttg atgcatttgg tattcatgga gctggaggaa ttgttggtgc
     3961 tattcttacc ggtgtttttc aatcacacta tgttaataat gatgtatcaa atggtttaat
     4021 ctatacagga gatgtacact caatcttaat tcaaatacta gctgttgtcg tggtattgtg
     4081 ttataccatt gttttaacat ggattatagg aaaaatttta cagaaaataa tgcctatcgc
     4141 tactactgaa gaagaagata aagcaggttt agatcaactt gttcatggtg agaaagccta
     4201 tttttatgga gaactaaaca aattaaataa gagatattga taatattatt aggataatac
     4261 atattaaaaa agttactttg agagattatt tctatgataa aataatcttt aaatgaaaat
     4321 taatttaggt gattaatcta atgaaaaata tatcagatat cgcaaaatta gcgggagtat
     4381 ctaaaagcac ggtctcccgc tttttaaatg gtggctcagt aagccatcaa actaaagaaa
     4441 aattaagtcg aattattgaa gaacatgatt atcagccgaa tcagtttgct caaagtttaa
     4501 gagctaaaca tacgaatctt attggtgcta tcattccaag gatgaattca catgcggttg
     4561 atgaaactgt gaaaggaatt gtatctgtat gccatcaaca tcaatatcaa ttattactta
     4621 actatactgg tttagatata cgtgctgaaa taggggcatt ggatacattt tcaagaagta
     4681 aagtggatgg cattatatta atggctacta ctttgactga tgaacacttg gaagtaattg
     4741 aaaaattaaa tgtaccggta attctggttg gacaatccta tcccaattta catagtataa
     4801 ttcatgatga ttatcaagct ggttttatag taggggaaca gatagggcgt aaaaagcata
     4861 aaaacgttgt attctttggt gtaagtgagg aggacgttgc tgtaggcatc aaacgtaaac
     4921 aaggtattat tgatggtttg aaaaaatacg atgtttatcc tgaaatttat ttaacttctt
     4981 ttagatatga agaggcaaaa aatgatgttt ctaagaagtt aaaaaatgct agaggtatcg
     5041 atgcgttaat tggagcaaca gatcctattg cattagcaat tcataaattt tattctcaac
     5101 aaaacaatgc tactggaaat tatcatattt ttggatttgg gggagaccca atgacacaac
     5161 ttgttacacc cgctattacg acagttaaat tcaattattt taaagctggc acatatgcta
     5221 tgaaccaatt gaatgaatta attttttcta aaaatgcagt atctaaaact gtcattcctg
     5281 ttgaaataga ggatttttaa aaatatttaa aactatggaa ccgataccat aatcaatgat
     5341 aaaattatat taactttaga tttaaattat tttggaggaa taatatggct gaatggtcaa
     5401 gagaagaacg ttatcgtcgt attgaagacg ttgataaaaa gtacttagaa aatctcaagc
     5461 aacaagttaa agcgtcaaga tttcgtcaaa tatttcatat tcaacctgaa actggtttgc
     5521 taaatgatcc taatggatta atttatcata acggcaaata ttatgtttca catcaatggt
     5581 tcccattagg agcagtgcat ggattgaaat attggtttaa ttatactagt gatgatttag
     5641 tggcatttga accacaagat accttaatca aacccgatac atattatgat agccatggtg
     5701 tttacagtgg tagtgctttt gatcataatg gagatttata ttacatgtat acaggcaatc
     5761 atcgtgatga acaatggaat cgatatgcta gtcagatgat tgctaaagtt caaagtaatg
     5821 gagagattac taaatttgat gaacccgtaa ttccttcaca acctgaaggg tatacaagtc
     5881 attttagaga tcctaaagtt tttgaattaa ataatgaata ttatgcgatt ataggtgctc
     5941 aaacaaacga ggaacttggt tgctgcttaa tttataaaac gaatgataag caactaaatc
     6001 aatggtcata ttgtggagaa attgatacta aattaaaaaa ctttggttat atgtgggaat
     6061 gtcccgatta ttttaaatta gattctaagg atatcttact gttcagccct cagggaatag
     6121 aaccacaagg ggatcagttt agaaatatat atcaatcagg ctatttaatt ggggatttaa
     6181 attttgattc attatccttt gatcatagtg aatttgtaga actggataat ggttttgatt
     6241 tttacgcacc ccaaactttt ttagatgaaa atggcaatcg agttttaata ggttggatgg
     6301 gcttgccaga aataaattat cctactgatg aagaaggatg ggcacattgt ttaacgatac
     6361 ctagagtact aacaatagag aataatcaat tacgacaacg cccgtttaaa ggtcttgaac
     6421 gattacgtaa aaataaagaa acggcattag gttatgcaaa taaatttaac cgaaaattac
     6481 atccatatga aggcaaacaa tatgaactaa ttattgatat tatcgaaaat gacgcttcaa
     6541 aaatttattt tgaattacgg acctcaaaac aaaataacac caaaattatc tacaatacaa
     6601 gggaacaaaa aattacatta gatcgctcag aaagtggatt attgcctgaa aatgttcaag
     6661 atttaacgag aagtacgata ttggattctc ctctcacacg tttgcaaata tttgttgata
     6721 catctagtat tgaaatattc tgtaatgatg gggaacgtgt tttaacatca agaatatttc
     6781 cagatgaaaa tgctacaggt atagaaactt caacggagac tggacaagta tatttaaaat
     6841 tcactaaata tgaacttaag gatgagtaaa aaatgagaaa gttatatggg ataggtgaag
     6901 cattaataga ttttattcca aatgttaaga actctgaact taaagatgtt gaacagttta
     6961 gtagacaggt tggaggtgca ccagctaatg ttgtgagtgt agctcgaaaa atgggtgcct
     7021 ccactgaaat ggtcactcaa ttaggtaatg atgcatttgg agacattatc gtagaaactt
     7081 taaaagatat tggtgtaggt actcaattta taaagcgaac agatcaagct aatactgcac
     7141 tagcatttgt gagtttaaaa gaagatggac aaagagattt ttcattttat cgtaaaccct
     7201 cagctgatat gctttataaa gctgaatatc taaatgaaat tacaatcaag ccaaacgatg
     7261 tattacattt ctgttctgtt gatttagttg aaagtaatat gaaagaagct cacaaatcta
     7321 tggtaaataa atttaagtca gcaaatgcaa ccattgtttt tgatcctaat gttcgtttac
     7381 ctctttggca aaatgctgaa gcatgtaaag aagcaattca tgaattttta ccgaaagcta
     7441 atgtgattaa aatttcagat gaagagctag aatttataac tggtgaagcg gatgaagata
     7501 aagctattca atcattattt gagggttctg tagaagcagt tatttatact caaggtgctg
     7561 caggtgcaag tatcatttta aaagatggga ctaagataca tcatggagga tttaaagtaa
     7621 aagcaattga tacaactggc gcaggggatg cctttatagg agctgcaata agtagaatgc
     7681 tattgagtga cgaattaaat attactaagt tgctaaaaga agaaggacag gacattctca
     7741 gatttagcaa catggtggcc gcaaaggtta caactaaata cggtgcaata gagagtattc
     7801 ctacaattga agatgttaca actgaattaa ataaatgata aaaagtgcca gtaaatgatt
     7861 ttattagttc atttactggc ttttttatac gtgatattct caattatttt tacttctgtg
     7921 atgaaattta tatttaaaaa gtttgataga cataactata tttttttaac attacgaacc
     7981 gaagcaaaac agtgctcacc gtttttaaaa ttgacaatac gttcttttga atctatggat
     8041 tcaatattat gtctgttaac aacgaagctg ttgtgacatc taaagaaccg ctcatcaagt
     8101 tgtgcaagtt cttttaaatt gccatagaac tcaatttgac gattatctaa atgtgcgatt
     8161 aatcgatgtg attttgtaga tgattcgaaa aacattacgt catcatattg aacataaatt
     8221 gaattacttc ctcgtttcaa ttcaatcgtt tcaacagtac tttctttaga taataatttt
     8281 aagcgagtgt gtgcagtttc taagcaatca ataattctgg actgtaattg gcttggatca
     8341 tctttaaaga taaaatccat tgctgacact ttgtaaacaa aggttaggta cgttaactca
     8401 ctatgacttg taacgaatat gatatttcca atagggtcat acttacgaat ttcactacct
     8461 aatttaatac cgttgatatc agcctctaat tgaatatcta gaaagtaaca tccgacatca
     8521 ttcatctctt tagatttttc aatgacttca taaggatcgt ctgttgcaag cgcaatctcc
     8581 ataggttttt cttcaatcat aatgtaatta ttaataattg aaaccatatt ttcacgttgt
     8641 tttacatcat cttcacaaat gaatattttc atgattacac atccttatga ctaattgtta
     8701 atgatttcta ctttttgtat aaagtagcca ttctctattg tggtatctag taatacattt
     8761 tcagtagaat cagtaatttc tttcagagta cttaatccta gacctctatt ttctcctttt
     8821 gttgaaaagc gttcttgaaa tagttcgtga atacgtggca tatcttcttt acatttattc
     8881 ataacaataa acatgacgga agagtctgta ttaataaaag cgatacgtat taatgcatct
     8941 tcaagcgttt cagatgcttc tattgcgtta tcagtaataa ttccaatgat acgactaaga
     9001 tcaatcgtgt tcatttctat atgttctact aactctggta cttctatgct aattggaatg
     9061 tttttttctt gagcttgtaa aattttagtg gtaactaagc ctttaatcgc acgtactttt
     9121 aaattctcag ttccattaat tttaatagac ttcatttgaa gattatcttt cataggtacg
     9181 atattttcat taaaatattg tcttaatcca ggcatatcat cttcacgaat atattcagac
     9241 attgtagtta agatgttcac ataatcatgt ctaaacttac gcatttcatt gttaattgac
     9301 tcaatttgta acgtatattc gtaatatgtt tcaatctctt ccatgttacg tttataacga
     9361 agttctttaa tcatatagtt agatatgaaa ataattagaa cagtaaagaa aagaataatt
     9421 ccaatgaaaa ttaaaccgta catttttaag gatgaattat ttatattagg tatttgagaa
     9481 taaacataca agataataaa agataaaact aatactaatg aaattatagt taaataagtt
     9541 ttgtttatag ataaataaga ttgcattagt ttttttaata aaatttgaac tgaaaaggcc
     9601 aaaactaatg aaatagcaaa aaatataact atgtatgaaa aggaaattat tacgtaattt
     9661 tgagtgtgct tttcaactaa aaccacgaat aaaaaaccta aaaaattact gaaaaacata
     9721 agaatagcgc tacttaatac agcaatcaat gaatacagct taaccttagt atataagatt
     9781 aagccacaac caattaataa atataaaatt gatatactgc ccaagtaaat aaataaaaag
     9841 gctgaaggga ttataaccac taaaatggct aaataatccc ttttagtata acttatgtct
     9901 aaaataattt tagcgattaa aaataagaga aacccttgaa aaaaagccaa tggaacgttt
     9961 gataatacat ccatacttct ctcacacttt ctaacattta ttatctattt aagttagtta
    10021 actcttcagg aacttctggc tcatcaaagt acgtagcaca tggagtataa gaagctaatg
    10081 tacctacaga ttctaataaa aatgagaaaa atttaataaa caaatcgaat aatactgtca
    10141 tagttaataa tcctccctag gaaaaaagat tggtaataat gtaatgctct caagtgtaat
    10201 tcctaataaa attaattgct taaacggttc tggtgctaaa aatgaaatta ttaataaaac
    10261 cattgttatg atgactgata ataacttctt tttcattttt aagtgactag gaattggttg
    10321 tttcttagtt gctgaagggg catagtaaat aattaaaaca gtcccaattg caactacaga
    10381 atacataata cccagattca cttgaaaata tactagcaac cagggtaatc ctacaaataa
    10441 agctaaattt tgaacatgac atagcaatgg tgattttgca tgtgccccgt gtgcataacg
    10501 tctaactaaa aaataactta catgtgtaaa taaagtgtat agaaatgtat ggaagataag
    10561 tgcaacacca tatgtcacaa ttgtttttga tagattgctt acaacaactt gtaatcccaa
    10621 tcttactttc aaaaattgaa tatgatcaag attatttttg cgttgcaaat ataatgcgaa
    10681 ttgctcaatc ttattatcaa ttgctttcaa tggtgtgcca ctctccttat atcaattata
    10741 caatttagtg caattggtct gggtacttat gcttaactgt tcaaaataaa tacctaactg
    10801 ttatattgaa attacaagta atattttaac atataaaata ttacagttat gtataaaaaa
    10861 atgcgattta agaaataatt aattatttat tcataggttg tgtttaaata gactcatatc
    10921 acttacaagt gataaaaact taataatctt agtctttaaa tttaatagtt attgtttggt
    10981 aattgagtta aataattttg tttgtagttg cgaaattatt gacaccttta ccatatgttg
    11041 taagtgttat taatggttat gaaaccattg caatagtagt aatgtcccat taatcattat
    11101 tactaaagtg acttcttgtt tatatgaagt ttcttacttg gttttcttcg tgtagttaaa
    11161 cgagttcatt aataagccat cccaacttat taatgaacta agtaaagtta ctgaagttta
    11221 aactcagtgg aaagtgttta acttagctat tgtaagatat agaagttaaa tattttcagg
    11281 atgtaagcta tcgtaaaatt ttcataatta ataacattcc caaaagattg aaataactgt
    11341 aaaaacattc ccttaatatg aaagtcgcga gttcctccca agctcgtgac tttttttgta
    11401 aaaaaaactg tatccattta attggataca gattagtaac tatttatata gatttggttt
    11461 taaatttttg aatacaggaa tattctcacg ttgaacatca acttcattta aatcaatatt
    11521 aaatgcgatt gtgtcctcat cctggcctaa ttcagctaat atatcaccat ttggattgat
    11581 aatcattgaa tgaccagcgt aatcagtatt actgtcattt ccagttccgt tacaagcaac
    11641 aacaaacatg tcattttcaa ttgcacgtgc ttgaagtaag actctccagt gattcaatct
    11701 aggtgttggc cattgagcta caaaaaaagc tatctgtgca ccattacgag cgggatatct
    11761 taataactct ggaaatctta aatcataaca aataatttgt gtagcttgag tacctgaaga
    11821 tagaggaaat ggttctggta ctgttttgcc atcttctaaa tatgtcggct catctagcat
    11881 agggactaag tgaactttat cgtacttatt tattctatgt ccgtttttag aaacggtaaa
    11941 tgcagtatta taaactttgc catttctaat atttgataca gatccagcta caatatcgac
    12001 gttatattgt ttagctaagg attggataaa gggaaagctt ctgctaagtt ctctatctgc
    12061 tttctcattt aattcatcca atgcatatcc gttattccac atttcaggaa gaacaacaac
    12121 ctctgtatct tcctccaatt tattttcgaa ccaatttatt attttatttt catttttttc
    12181 tacattgccg tatgatacat aaaattgaaa taattgtatt ttcatttaaa aatctcctca
    12241 tcccatgatt atctctaatt tactaaaata gaataagaaa atcaaaattt gaaagtgatg
    12301 attaaaatgc tttatttttg aaaataaata taaaaaggac tcaatttcaa catagaaatg
    12361 aatcatagag aaactgagtc ttgaattgtt aatctaatcg atatcaatga atgtagatta
    12421 ttttttaatt attaatctat tgttagttgg ttgtatttct ttttcaccag ctttttcacg
    12481 gatgtcacca aatggcattt gagcaacaag tttccatgaa gcagggatgt caaattcttg
    12541 tgtagtgatt tgatctacta aaggattgta atgttgtaat gaagcgccaa ttccttttga
    12601 acttaatgca gtccaaattg caaattgatg cattgcgttt gtttgaactg accaattagc
    12661 aaagttatca gcataatttg gcatttgttc ttgtaaacct ttaatcacat cttcgtcttc
    12721 gaaataaaga attgtgccat atgcatgttt aaatccgtcg atacgttgtt cagttggagt
    12781 gaaatcacgg tcaggtccca tcacatcttt taatactatt ttagtattgt cccaaaattt
    12841 gtgatgttga tcatttaata acaaaacgat tctagtagat tgagaattaa aagcagaagg
    12901 agtgtattta ataatatgtt ctatcatatc ttctagttct ttatcactga ttgaaattgt
    12961 tgtttcagtg ctatagatag tacgtctatc ttcgatttct tgtaaaaatg gttttgtttt
    13021 tgatttgcta aataagccca tgttaaatct tctttgttta tataagttat atctctagta
    13081 taaatattat acttaaatat gtaaaatgtt tttaacaaaa aatgtcaaaa atattaatat
    13141 tttttatcat taaccttatt tcaatgcatt atatgtaaat attctttata ctgtaagtgt
    13201 tataaaacaa ggaggtggaa gattgatgaa aaagaaaata gctcatacag gtctcatttt
    13261 agctctaggc acatctatgc taggaaatga gaacgtcgta aaagctgtag aaaataatca
    13321 acaggctacg aatgaagtta atagtagtaa ggttagttca gacacggata cccaagaacg
    13381 tcaaaatagt agtaataaca tcaatgaaaa tcatcaatct gatacccaag attcaactca
    13441 attagaaaaa aataataata atcaaaatag cggtgaaagc gatacatcat caaataacga
    13501 gaatgatgct aatcaaaata gtgataatac tgtggatcaa agtaacgcat ctgataatag
    13561 taactcaggc agtaatactg atttaaataa tggtgatgac acaaataatt ctggagacaa
    13621 tgatacaatc aatccgaatg atggagagca accaggagat aatgattcat c
//
